max in WT synaptoneurosomes, suggesting that Src signaling could possibly be downregulated in KI synapses. Alternatively, our ability to rescue SERT purpose in KI midbrain synaptoneurosomes by the inhibition of FAK signifies elevated FAK signaling downstream of your Pro32Pro33 mutant, as verified by greater pFAK localization in 5-HT synapses. Our d